Organismal Aging and Survival

In the simplest terms, within almost all multicellular organisms two cell types exist: dividing (mitotic) and nondividing (postmitotic). It is abundantly clear that mechanisms to ensure fidelity of the genetic material, DNA damage response, cell cycle checkpoint control, and telomere replication and maintenance are essential for the life span of dividing cells, as defects in these processes lead to increased cellular senescence. However, it is less clear how these processes impinge upon the aging and survival of nondividing cells, such as neurons, muscle cells, and gametes. Therefore, a central question within the aging field has become to determine whether the same processes required for genome integrity of dividing cells are required for the aging of terminally differentiated cells.

0 0

Post a comment