Conclusions

The emphasis in PRD1 research is becoming more holistic. Active areas are virus-host cell interactions, detailed linkage of atomic resolution structure to function, and virus evolution. The possibility of exploring this complex system in such detail arises because of the fundamental knowledge that has already accrued.

Note added in proof: The X-ray structure of the virion and the C-terminal domains of protein PS are now available (Abrescia et al., 2004, Nature 432, 68-74; Cockburn et al., 2004, 432, 122-125; Merckel et al., 2005, Mol. cell, April issue).

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