Conclusions

C. elegans offers a genetically and developmentally accessible system for exploring how the positive cell cycle components (such as the cyclins and their Cdk partners), and the negative components (for example, cullins and CKIs) can be linked to developmental pathways in specific cells. The pathway regulating dauer larva formation, and the heterochronic gene pathway, represent examples of pathways affecting global and tissue specific cell cycle control, respectively. One challenge will be to understand the sometimes reciprocal interplay between developmental pathways and the cell cycle machinery. We wish to know how developmental regulators interact with cell cycle machinery to control developmental patterns of cell division. We also want to understand how the cell cycle machinery can influence cell fate choices made by progenitor cells or differentiating cells.

.Acknowledgements

I apologize to anyone whose work has received inadequate discussion here because of space constraints. I am grateful to Richard Roy, Michael Krause, and Paul Sternberg for helpful discussions. Work in my laboratory is supported by PHS grant # GM34028.

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