Actions of Drugs at 5HT1 Receptors

Systemic administration of 5-HT1A receptor agonists such as 8-OH-DPAT in rats reduces penile erections induced by 5-HT2C agonists36 and facilitates ejaculation by decreasing ejaculatory threshold and latency (Table 6.1).37 Administration of 8-OH-DPAT causes a

SSRIs and Sexual Function

85

Table 6.1. Summary of the effects of 5-HT receptor activation in male and female rats

Receptor

Effect of receptor activation

Male

5-HT-IA & 5-HT2A 5-HT2C

Reduces erection & increases ejaculation Increases erection & reduces ejaculation

Female

5-HTia & 5-HT2A 5-HT2C

Receptive Non-Receptive Inhibits lordosis stimulates lordosis Stimulates lordosis Inhibits lordosis

biphasic dose-response pattern in the rhesus monkey. Low doses facilitated ejaculation by reducing ejaculatory threshold and latency, perhaps by a preferential presynaptic action as seen in other models of 5-HT1A receptor function,38 and high doses interfered with copulation and ejaculation.39

Intrathecal administration of lisuride40 and the more selective 5-HT1A receptor agonist 8-OH-DPAT,35 however, has a facilitatory effect on male sexual behavior with reduced number of mounts and intromissions before ejaculation, and reduced ejaculation latency.

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