John A Henry and Carol A Rivas

The selective serotonin reuptake inhibitors (SSRIs) have increased in popularity and extent of use since their introduction. At the same time, our knowledge concerning the relationship between suicide and depression has increased. The impact of this group of drugs on this knowledge has been considerable. An additional consideration is that, as with all drugs and particularly with antidepressants, they are liable to be taken in overdose. This chapter reviews some of the links between the SSRIs and depression, overdose and suicide.

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