Analytic studies focus on determinants of a disease and are often set up to test hypotheses generated from previous descriptive studies. Analytic studies are designed to determine whether certain exposures cause (or prevent) a disease of interest. The general approach for analytic studies is first to define the outcome (disease) of interest, then to identify the exposed and unexposed groups. The choice of analytic design depends on the features of the exposure and the disease, the current state of knowledge regarding the hypothesis of interest and, finally, the available time and financial resources. The methodological issues discussed in the first section of this chapter pertain to the design and conduct of all types of analytic studies of the late effects discussed below.
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