Diabetes insipidus may be caused by histiocytosis, germinomas, surgical trauma or CNS-involved leukemia. Patients with diabetes insipidus usually present with obvious symptoms of excessive thirst and urination with nocturia or enuresis. However, diabetes insipidus may not be recognized until affected patients have dehydration during an intercurrent illness. The urine remains clear in color throughout the day. In patients with CNS-involved leukemia, severe hypernatremic dehydration can occur if the CNS lesion also affects the centers for thirst regulation.
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