Cellular and organismal aging is influenced by multiple parameters, such as telomere length, telomere shortening rates, the DNA damage response machinery, dietary restriction, mitochondrial metabolism, and the insulin-signaling pathway. Currently it is not well understood how these pathways interact, how the determinants of organismal life span influence cellular aging, and how or if the cellular clock limits organismal longevity. It remains a unique challenge to the aging research community to integrate the various aspects of the field, to realize the connections to age-related diseases, and to exploit these realizations for healthy aging.

Acknowledgements We would like to thank the NIH and NIA for funding, and Marcela Raices and Regina Kirchweger for comments on the manuscript.

Supplements For Diabetics

Supplements For Diabetics

All you need is a proper diet of fresh fruits and vegetables and get plenty of exercise and you'll be fine. Ever heard those words from your doctor? If that's all heshe recommends then you're missing out an important ingredient for health that he's not telling you. Fact is that you can adhere to the strictest diet, watch everything you eat and get the exercise of amarathon runner and still come down with diabetic complications. Diet, exercise and standard drug treatments simply aren't enough to help keep your diabetes under control.

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