Figure 10-4 Alignment of representatives of the S21 class II holin family. Sequences are compared with SPA2. Changes within either TMD resulting in increased or decreased side-chain bulk is indicated by shading or boxes, respectively. Dlp12 and Qin are cryptic lambdoid prophages of E. coli K-12 (90). PA2 is the lambdoid prophage of a porcine strain of E. coli (16). 933W is the lambdoid prophage carrying the Shiga-like toxin gene in the hemorrhagic E. coli strain 0157:H7 (86).

to make a holin is not clear, although the available evidence suggests the ability to oligomerize is important (see How Do Holins Work?).

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