Isbn 0792337271

Dickson, R.B., Lippman, M.E. (eds.) Mammary Tumor Cell Cycle, Differentiation and Metastasis. 1995. ISBN 0-7923-3905-3. Freireich, E.J, Kantarjian, H. (eds) Molecular Genetics and Therapy of Leukemia. 1995. ISBN 0-7923-3912-6. Cabanillas.F., Rodriguez, M.A. (eds) Advances in Lymphoma Research. 1996. ISBN 0-7923-3929-0. Miller, A.B. (ed.) Advances in Cancer Screening. 1996. ISBN 0-7923-4019-1. Halt, W.N. (ed.) Drug Resistance. 1996. ISBN 0-7923-4022-1. Pienta, K.J. (ed.) Diagnosis and Treatment...

Conclusion

Targeting growth factor-mediated signaling offers a paradigm for treating cancer. While past efforts focused on the effects of cytotoxic therapies with chemotherapy and radiation therapy, the future looks towards the integration of molecular targeted therapies into current treatment modalities. Given the primarily cytostatic nature of growth factor-targeted biological therapy, its role is likely to be administration in combination with cytotoxic therapy for tumor eradication, and in exploring...

Trks And The Regulation Of Cancer Growth

The regulation of cell number during development or in cancer growth reflects a balance of signals that promote proliferation or differentiation and survival or apoptosis. Neurotrophin activation of Trks helps to determine this balance during development and oncogenesis. Thus in cancer Trks can be helpful or hurtful biological modifiers and positive or negative prognostic indicators. Trk activities have been described in diverse cancers arising from many tissues including medullary thyroid...