Our work on the Drosophila IDGFs supports the idea that the mammalian relatives might contribute to inflammatory disease by acting as mitogens on fibroblasts and perhaps other cell types. If confirmed, this finding opens up major new opportunities for rational drug design for some common and debilitating disorders. As far as we are aware, none of the mammalian proteins has been tested for any interaction with the insulin pathway. The identification and analysis of the IDGFs should help in understanding the functions of these mammalian family members and their relationships to disease states.

Diabetes 2

Diabetes 2

Diabetes is a disease that affects the way your body uses food. Normally, your body converts sugars, starches and other foods into a form of sugar called glucose. Your body uses glucose for fuel. The cells receive the glucose through the bloodstream. They then use insulin a hormone made by the pancreas to absorb the glucose, convert it into energy, and either use it or store it for later use. Learn more...

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