Paraneoplastic Retinal Degeneration or Cancer Associated Retinopathy

Sera from patients with paraneoplastic retinal degeneration or cancer-associated retinopathy contain antibodies

binding antigens that are both a photoreceptor cell-specific protein and a protein expressed by small cell lung cancer. y Pathologically, widespread degeneration of the outer retinal layers with relative preservation of the other retinal layers occurs. This syndrome is usually associated with small cell lung cancer but is also observed with other tumors, including melanoma and cervical cancer. The distinctive clinical triad consists of photosensitivity, ring scotomatous visual field loss, and attenuated caliber of retinal arterioles. y

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