The Leptin Receptor

Beta Switch Program

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The leptin receptor (ObR) is a member of the cytokine receptor superfamily and is coded for by the diabetes gene db7~9. Mice with dbjdb mutation have the same obese phenotype as ob/ob mice. The db gene encodes at least five alternatively spliced forms of the receptor ObR-a-e in mice and four in humans9-". The ObR b is the full-length receptor and is essential for the weight-reducing effects of leptin. ObR a is expressed in the choroid plexus and other tissues but its function is unknown. It has some weak signalling activity. The functions of the ObR-c, -d and -e forms are also unknown but may be involved in transport or form heterodimers with the other forms'.

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