Modeling and Simulation as a Teaching Tool

University of Auckland, Auckland, New Zealand Mats O. Karlsson University of Uppsala, Uppsala, Sweden This chapter briefly reviews the history of clinical trial simulation and applications of how it might be used for teaching in an academic setting. 11.2 HISTORY OF CLINICAL TRIAL SIMULATION The history of clinical trial simulation and recent applications have been reviewed by Holford et al. (1). Early clinical trial simulators were based solely on predicting the stochastic aspects of how...