The influence of hormones on erection

Penis Size Hormone Blocker Patient

Both fetal and later phallic growth are dependent on T and DHT tissue concentrations and androgen receptor density. At the cerebral level, testosterone stimulates the synthesis, storage and release of pro-erectile neurotransmitters such as dopamine, NO and oxytocin 14,24,46,47 . At the spinal level the somatic motoneurons of the bulbo- and ischiocavernous muscles are T dependent (Fig. 3.8). At the corpus cavernosum level, NOS-containing parasympathetic nerves are T dependent 48 . Recent studies...

Complications of penile prosthetic surgery and their management

Erectile Radiology

The typical complication that may occur during dilation of the corpora cavernosa is perforation of the tunica albuginea. Typically the perforation occurs during the initial step of dilatation if this is the case, interrupting the dilatation on that side and completing the same procedure contralaterally will show the real length of the crus. With a size nine Hegar dilator in place in the corpus cavernosum contralateral to the perforation, the surgeon should go back to the crus affected by the...

Drug combinations for selfinjection therapy

Penile Self Injections Demonstration

PGE1 is still the first line option for patients who either do not respond or show contraindications for oral phosphodiesterase-5 inhibitors. Besides PGE1 mono therapy, several potentially useful combinations have been used for self-injection therapy as second line options. The vasoactive agents most commonly used in combination therapy, were phen-tolamine, papaverine, PGE1, and VIP. Potential advantages of the use of combination therapies over mono therapy may depend on the number of drugs...

Types of Penile Prosthesis

Penile implants are currently available in a variety of forms, which can be categorized into two major types semi-rigid, or inflatable, with a silicon or polyurethane jacket. Details of the available length and diameters can be found on the websites of the two manufacturing companies American Medical Systems at www.visitams.com and the Mentor Corporation at www.mentorcorp.com. When implanted into the corpora cavernosa, they can be manipulated by the patient to fit his needs. The Jonas implant,...

Melanocortin receptor MCR agonists

Presently there are five MCRs identified and all five are activated by adrenocorticotropin hormone (ACTH) and four out of five, except MC2R, by alpha-melanocyte stimulating hormone (a-MSH) 1 . Of the five MCRs only two (MC3R and MC4R) are expressed in cerebral regions known to be involved in the modulation of erectile function. The origin of both a-MSH and ACTH is the pro-opiomelanocortin (POMC) gene, and the biologic effects of these two hormones are mediated via activation of one or more of...