Female rats treated with the opioid antagonist naloxone during paced copulatory trials do not form conditioned place or partner preferences. Such pref erences are typically examined on a final test, when the drug is not administered (thus revealing the necessity of opioid reward during paced copulation). However, during this final test without the drug, females previously treated with naloxone display a conditioned disruption of solicitation and lordosis relative to saline-treated females, despite being primed fully with estrogen and progesterone. As a result, males engage in fewer intromissions and achieve fewer ejaculations with those females. A pattern of diminished sexual solicitation and receptivity, which leads to more restricted sexual contact with males, is analogous in many ways to the pattern of sexual behavior displayed by women with hypoactive sexual desire disorder. It is not yet known if this pattern of disrupted appetitive sexual behavior can be restored by pharmacologic or experiential treatments that increase desire in women.
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