Glycopyrrolate inhibits secretion of digestive juices and restores normal stomach function. It is used for treating stomach ulcers, inflamed intestine, and also as a pre-operational drug for inhibiting excess stomach secretion. A synonym of this drug is robinul.
Isopropamide: Isopropamide, (3-carbamoyl-3,3-diphenylpropyl)di-iso-propylmethyl ammonium iodide (14.1.25), is synthesized by alkylating diphenylacetonitrile with di-iso-propylaminoethylchloride in the presence of sodium amide, and the subsequent hydrolysis of the nitrile group of the resulting compound (14.1.23) to an amide group (14.1.24). Alkylation of this compound with methyliodide gives isopropamide (14.1.25) [19-22].
Isopropamide inhibits muscarinic action of acetylcholine on postganglionic parasym-pathetic effector regions. It is used for treating stomach ulcers and inflamed intestine. Synonyms of this drug are darbid and mobadid.
Hexocyclium: Hexocyclium, 4-(/i-cyclohexyl-/i-hydroxyphenethyl)-1,1-piperazinium methylsulfate (14.1.28), is synthesized by alkylating 1-methylpiperazine with a-brom-acetophenone, which forms 4-methyl-1-phenacylpiperazine (14.1.26). Reacting this with cyclohexylmagnesiumbromide gives 4-(^-cyclohexyl-^-hydroxyphenethyl)-1,1-piper-azine (14.1.27), the alkylation of which using dimethylsulfate gives hexocyclium .
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