Directacting Cholinomimetics

Direct-acting cholinomimetics are drugs that act directly by stimulating cholinergic receptors. These drugs are divided into drugs that stimulate muscarinic (M-cholinoreceptors) or nicotinic (N-cholinoreceptors) receptors. Drugs whose efficacy is primarily connected to stimulation of muscarinic receptors, including choline esters, i.e. acetylcholine and its structural analogues, which are methacholine, carbacholine, betanechol, and natural alkaloids muscarine and pilocarpine. Drugs whose action is based on stimulation of nicotinic receptors include the alkaloids nicotine and lobeline.

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