Paromomycin: From a chemical point of view, paromomycin, O-2-amino-2-deoxy-a-D-glucopyranosyl(1^4)-O-[O-2,6-diamino-2,6-dideoxy-ß-L-idopyranoxyl-(1^3)-ß-D-ribofuranosyl-(1^5)]-2-deoxy-D-streptamine (32.4.5), differs from neomycin B only in the replacement of the 6-amino group in the glucopyranosyl region of the molecule with a hydroxyl group, and it is isolated from a culture fluid of the actinomycete S. rimosus [256-258].
The antibacterial activity and indications for using paromomycin are analogous to those of neomycin. In addition, it is recommended for treating severe and chronic forms of gastric amebiasis. Synonyms of this drug are aminosidine, catenulin, crestomycin, hydroxymycin, monomycin, zygomycyn, and others.
Kanamycin: Kanamycin, 0-3-amino-3-deoxy-a-D-glucopyranosyl-(1^6)-O-[6-deoxy-6-amino-a-D-glucopyranosyl-(1^4)]-2-deoxy-D-streptamine (3.4.6), is isolated from a culture liquid of the actinomycete S. kanamyceticus, which produces three antibiotics— kanamycines A, B, and C [259-262].
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