What was the evidence in 1981 Cumulative metaanalysis

Myocardial Infarction Blocker

What conclusions would our junior doctor have reached if she had had access to a meta-analysis Numerous meta-analyses of trials examining the effect of beta-antagonists have been published since 1981.17,45-48 Figure 1.4 shows the results from the most recent analysis that included 33 randomised comparisons of beta-blockers versus placebo or alternative treatment in patients who had had a myocardial infarction.48 These trials were published between 1967 and 1997. The combined relative risk...

Example 3 trials of BCG vaccine against tuberculosis

The following table is based on a meta-analysis by Colditz et al.20 which examined the efficacy of BCG vaccine against tuberculosis. Trial Trial name Authors Start Latitude* Intervention Control Trial Trial name Authors Start Latitude* Intervention Control * Expressed in degrees from equator. * Expressed in degrees from equator. The data were saved in Stata dataset bcgtrial.dta. Scientists had been aware of discordance between the results of these trials since the 1950s. The clear heterogeneity...