E

Control SP

FIGURE 7.3 Effect of Spirulina (SP) on cisplatin (CP)-induced lipid peroxidation (MDA). Rats were treated CP (6 mg/kg b.w. single dose, i.p) and Spirulina (1 g/kg) was administered orally, 3 days prior to CP treatment and continued till end of the experiment. Values are expressed as mean ± SD (n = 6), *p < .05 vs. control; **p < .05 vs. CP. The results show that Spirulina treatment attenuated the CP-induced increase in lipid peroxidation.

Control SP

FIGURE 7.3 Effect of Spirulina (SP) on cisplatin (CP)-induced lipid peroxidation (MDA). Rats were treated CP (6 mg/kg b.w. single dose, i.p) and Spirulina (1 g/kg) was administered orally, 3 days prior to CP treatment and continued till end of the experiment. Values are expressed as mean ± SD (n = 6), *p < .05 vs. control; **p < .05 vs. CP. The results show that Spirulina treatment attenuated the CP-induced increase in lipid peroxidation.

recent study has demonstrated that the treatment with a Spirulina-enriched diet has lowered the ischemia-reperfusion-induced apoptosis and cerebral infarction by inhibiting the caspase-3 activity.99 Spirulina treatment does not appear to interfere with the anticancer efficacy of cisplatin treatment.40 One possible crucial mechanism that needs further investigation is the attenuation of the cisplatin-induced oxidative stress and apoptosis by Spirulina.

Spirulina has been also shown to protect against the cyclosporine-induced neph-rotoxicity in rats.107 In this study, pretreatment with Spirulina has significantly

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