Nondialyzable extracts of some vegetables such as spinach induced the differentiation of other myeloid leukemia and promyelocytic cell lines U937 and HL-60 cells, respectively.49 All-trans-retinoic acid and vitamin D3 are known as being among the physiologic agents that can modulate the proliferation and differentiation of hema-topoietic cells.50 Vitamin plus IFNy treatment and enrichment with polyunsaturated fatty acids such as arachidonic acid, eicosapentaenoic acid or docosahexaenoic acid also significantly enhanced the expression of monocytic surface antigens CD11b and CD14 on human premonocytic U937 cells and resulted in enhancement of immun-oregulatory effects.51 In addition to our present results, it can be suggested that Spirulina is useful in providing complementary nutrients for modulating or maintaining the immune system and that it also may have potential therapeutic benefits for improvement of weakened immune functions caused by, for example, the use of anti-cancer and anti-infectious drugs or HIV-related diseases.
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