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Control SP CP CP + SP

Control SP CP CP + SP

Control SP CP CP + SP

Control SP CP CP + SP

FIGURE 7.4 Effect of Spirulina (SP) on cisplatin (CP)-induced changes in SOD (a), catalase (b), and glutathione peroxidase (c). Rats were treated CP (6 mg/kg b.w. single dose, i.p ) and Spirulina (1000 mg/kg) was administered orally, 3 days prior to CP treatment and continued till end of the experiment. Values are expressed as mean ± SD (n = 6), *p < .05 vs. control; **p < .05 vs. CP. The results show that Spirulina treatment attenuated the CP-induced decrease in SOD, catalase, and glutathione peroxidase.

Control SP CP CP + SP

FIGURE 7.4 Effect of Spirulina (SP) on cisplatin (CP)-induced changes in SOD (a), catalase (b), and glutathione peroxidase (c). Rats were treated CP (6 mg/kg b.w. single dose, i.p ) and Spirulina (1000 mg/kg) was administered orally, 3 days prior to CP treatment and continued till end of the experiment. Values are expressed as mean ± SD (n = 6), *p < .05 vs. control; **p < .05 vs. CP. The results show that Spirulina treatment attenuated the CP-induced decrease in SOD, catalase, and glutathione peroxidase.

attenuated the cyclosporine-induced nephrotoxicity and this effect has been attributed to its antioxidant property. Pretreatment of rats with Spirulina has resulted in significant attenuation of cyclosporine-induced increase in plasma urea and creatinine (Figure 7.5). Histological study of the kidney in the cyclosporine-treated rats reveals severe isometric vacuolization and widening of interstitium (Figure 7.6). Rats treated with cyclosporine and Spirulina together have shown a normal tubulo-interstitial pattern with fewer isometric vacuolization. In the cyclosporine-treated rats, there has been a significant increase in the extent of lipid peroxidation (MDA) of plasma and kidney as compared to that in the control animals (Table 7.1). Spirulina pretreatment has caused a significant attenuation of the cyclosporine-induced decrease in the activities of SOD, catalase and glutathione peroxidase in the kidney (Table 7.1). Also, it should be emphasized that Spirulina offers protection against the cyclosporine-induced nephrotoxicity without interfering with the metabolism of cyclosporine.107 Several reports have established that apoptosis is involved in the cyclosporine-induced renal injury.115,127 Our earlier investigation revealing that Spirulina attenuates the doxorubicin-induced apoptosis and

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