TABLE 2.5 Continued

Effects against Animals




Neurotoxicity Rats

Ocular toxicity Rats

Ovary toxicity Rats

Testicular Mice toxicity


Methods and results summary Reference

Pretreatment with Spirulina (500 mg/kg) protected 112

against cyclosporine-induced nephrotoxicity and prevented MDA rise in plasma and kidney tissues, isometric vacuolization and interstitial widening. These results suggested a crucial role played by Spirulina, given its antioxidant properties.

Spirulina (500, 1000, 1500 mg/kg) restored renal 113

functions, decreased lipid peroxidation, and increased previously reduced glutathione levels, superoxide dismutase, and catalase activities in gentamycin induced renal dysfunction.

Oral Spirulina (1000 mg/kg) pretreatment buffered 114

increased plasma urea, creatinine, urinary beta-W-acetyl-(D-glucose-aminidase), and plasma and kidney MDA as well as histomorphological changes in cisplatin-induced nephrotoxicity. This effect was attributed to its antioxidant properties.

Oral pretreatment with phycocyanin (100 mg/kg) 115

protected against kainic acid-induced hippocampus neuronal damage. Equivalent results were found in peripheral benzodiazepine receptors and heat shock protein 27 kD expression. Antioxidant effects of this protein were suggested.

Lens glutathione, soluble protein and water content 21

profiles showed a preventive effect of Spirulina at 1500 mg/kg doses in a naphthalene induced cataract model.

Spirulina (300 mg/kg) showed a protective effect 116

against lead-induced alterations in the number of mast cells in the cortex and medulla of rat ovaries during the oestrus cycle.

Spirulina (800 mg/kg) given to males treated with lead 89 for 30 days showed a significant recovery and less damage on histology, testes weight, tubular diameter, cell types, primary and secondary spermatocytes, and spermatids. The effect may be attributed to the presence of beta-carotene and superovide dismutase (SOD) enzymes.

Spirulina given before or after mercury induced 117

toxicity in testis protected the animals by increasing acid and alkaline phosphatase activity levels. The effect was attributed to the high ^-carotene content and its antioxidant activity.

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