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1. Khan, Z., Bhadouria, P., and Bisen, P.S., Nutritional and therapeutic potential of Spirulina, Curr. Pharm. Biotechnol., 6, 373, 2005.

2. Venkataraman, L.V. et al., Simplified method of raising inoculums of blue green algae Spirulinaplatensis for rural application in India, Phykos, 21, 56, 1982.

3. Dillon, J.C. and Phan, P.A., Spirulina as source of protein in human nutrition, Bull. Inst. Oceanogr., 12, 103, 1993.

4. Kapoor, R. and Mehta, U., Utilization of beta-carotene from Spirulina platensis by rats, Plant Foods Hum. Nutr., 43, 1, 1993.

5. Annapurna, V.V., Deosthale, Y.G., and Bamji, M.S., Spirulina as a source of vitamin A, Plant Foods Hum. Nutr., 41, 125, 1991.

6. Mitchell, G.V. etal., Effects of graded dietary levels of Spirulina maxima on vitamins A and E in male rats, J. Nutr, 120, 1234, 1990.

7. Cases, J. et al., Assessment of selenium bioavailability from high-selenium Spirulina. subfractions in selenium-deficient rats, J. Agric. Food Chem., 50, 3867, 2002.

8. Yoshida, A., Takagaki, Y., and Nishimume, T., Enzyme immunoassay for phycocyanin as the main component of Spirulina color in foods, Biosci. Biotechnol. Biochem, 60, 57, 1996.

9. Cohen, Z., Products from microalgae, in Handbook of Microalgal Mass Culture, Richmond, A., Ed., CRC Press Inc, Boca Raton, FL, 1986, 421.

10. Glazer, A.N., Phycobiliproteins—a family of valuable, widely used fluorophores, J. Appl. Phycol, 6, 105, 1994.

11. Bhat, V.B. and Madyastha, K.M., Scavenging of peroxynitrite by phycocyanin and phycocyanobilin from Spirulina platensis: protection against oxidative damage to DNA, Biochem. Biophys. Res. Commun, 285, 262, 2001.

12. Miranda, M.S. et al., Antioxidant activity of the microalga Spirulina maxima, Braz. J. Med. Biol. Res, 31, 1075, 1998

13. Bhat, V.B. and Madyastha, K.M., C-Phycocyanin: a potent peroxyl radical scavenger in vivo and in vitro, Biochem. Biophys. Res. Commun, 275, 20, 2000.

14. Wu, L.C. et al., Antioxidant and antiproliferative activities of Spirulina and Chlorella water extracts, J. Agric. Food Chem, 53, 4207, 2005.

15. Benedetti, S. et al., Antioxidant properties of a novel phycocyanin extract from the blue-green alga Aphanizomenon flos-aquae, Life Sci., 75, 2353, 2004.

Galli, F., Canestrari, F., and Bellomo, G., Pathophysiology of oxidative stress and its implication in uremia and dialysis, Contrib. Nephrol, 127, 1, 1999. Parthasarathy, S. et al., Oxidative stress in cardiovascular disease, J. Nucl. Cardiol., 8, 379, 2001.

Cooke, M.S. et al., Oxidative DNA damage: mechanisms, mutation, and disease, FASEBJ, 17, 1195, 2003.

Beal, M.F., Aging, energy, and oxidative stress in neurodegenerative diseases, Ann. Neurol., 38, 357, 1995.

Markesbery, W.R., Oxidative stress hypothesis in Alzheimers disease, Free. Radic. Biol. Med., 23, 134, 1997.

LeBel, C.P. and Bondy, S.C., Oxidative damage and cerebral aging, Prog. Neurobiol., 38, 601, 1992.

Gey, K.F., Vitamins E plus C and interacting conutrients required for optimal health. A critical and constructive review of epidemiology and supplementation data regarding cardiovascular disease and cancer, Biofactors, 7, 113, 1998. Upasani, C.D. and Balaraman, R., Protective effect of Spirulina on lead induced deleterious changes in the lipid peroxidation and endogenous antioxidants in rats, Phytother. Res., 17, 330, 2003.

Gemma, C. et al., Diets enriched in foods with high antioxidant activity reverse age-induced decreases in cerebellar beta-adrenergic function and increases in proin-flammatory cytokines, J. Neurosci., 22, 6114, 2002.

Romay, C. et al., Antioxidant and anti-inflammatory properties of C-phycocyanin from blue green algae, Inflamm. Res., 47, 36, 1998.

Romay, C., Ledón, N., and González, R., Further studies on anti-inflammatory activity of phycocyanin in some animal models of inflammation, Inflamm. Res., 47, 334, 1998. Kehrer, J. P. and Smith, C.V., Free radical in biology: sources, reactivities, and roles in the etiology of human disease, in Natural Antioxidants in Human Health and Disease, Frei, B., Ed., Academic Press, San Diego, CA, 1994, 25.

Reddy, M.C. et al., C-Phycocyanin, a selective cyclooxygenase-2 inhibitor, induces apoptosis in lipopolysaccharide-stimulated RAW 264.7 macrophages, Biochem. Biophys. Res. Commun., 304, 385, 2003.

Remirez, D. et al., Inhibitory effects of Spirulina in zymosan-induced arthritis in mice, Mediators Inflam, 11, 75, 2002.

Kumar, M., Sharma, M.K., and Kumar, A., Spirulina fusiformis: a food supplement against mercury induced hepatic toxicity, J. Health Sci., 51, 424, 2005. Dasgupta, T. et al., Chemomodulation of carcinogen metabolising enzymes, antioxidant profiles and skin and forestomach papillomagenesis by Spirulina. platensis, Mol. Cell Biochem, 226, 27, 2001.

Mathew, B. et al., Evaluation of chemoprevention of oral cancer with Spirulina fusiformis, Nutr. Cancer, 24, 197, 1995.

Gorban, E.M. et al., Clinical and experimental study of Spirulina efficacy in chronic diffuse liver diseases, Lik. Sprava., 6, 89, 2000.

Parij, V.B., Bagym, A.N., and Neve, J., Linear and non-linear competition plots in the deoxyribose assay for determination of rate constants for reaction of non steroidal anti-inflammatory drugs with hydroxyl radicals, Free Rad. Res., 23 , 571, 1995.

Padyana, A.K. et al., Crystal structure of a light-harvesting protein C-phycocyanin from Spirulina platensis, Biochem. Biophys. Res. Commun, 282, 893, 2001. MacColl, R., Allophycocyanin and energy transfer, Biochim. Biophys. Acta (Bioen-ergetics), 1657, 73, 2004.

37. Williams, C.S., Mann, M., and DuBois, R.N., The role of cyclooxygenases in inflammation, cancer, and development, Oncogene, 18, 7908, 1999.

38. Dannenberg, A.J. etal., Cyclooxygenase 2: a pharmacological target for the prevention of cancer, Lancet Oncol., 2, 544, 2001.

39. Bandoopadhyay, G.K. et al., Linoleate metabolites enhance the in vitro proliferative response of mouse mammary epithelial cells to epidermal growth factor, J. Biol. Chem., 262, 2750, 1987.

40. Marnett, L.J., Aspirin and the potential role of prostaglandins in colon cancer, Cancer Res., 52, 5575, 1992.

41. Sheng, H. et al., Modulation of apoptosis and Bcl-2 expression by prostaglandin E2 in human colon cancer cells, Cancer Res., 58, 362, 1998.

42. Lu, X. et al., Nonsteroidal antiinflammatory drugs cause apoptosis and induce cyclooxygenases in chicken embryo fibroblasts, Proc. Natl. Acad. Sci. USA, 92, 7961, 1995.

43. Pardhasaradhi, B.V.V. et al., Phycocyanin-mediated apoptosis in AK-5 tumor cells involves down-regulation of Bcl-2 and generation of ROS, Mol. Cancer Ther., 2, 1165, 2003.

44. Vadiraja, B.B., Gaikward, N.W., and Madyastha, K.M., Hepatoprotective effect of C-phycocyanin: protection for carbon tetrachloride and R-(+)-pulegone-mediated hepatotoxicity in rats, Biochem. Biophys. Res. Commun., 249, 428, 1998.

45. Kushak, R.I., Drapeau, C., and Van Cott, E.M., Favorable effects of blue-green algae Aphanizomenon flos-aquae on rat plasma lipids, JANA, 2, 59, 2000.

46. Lee, A.V. and Werth, V.P., Activation of autoimmunity following use of immunos-timulatory herbal supplements, Arch. Dermatol., 140, 723, 2004.

47. Pugh, N. et al., Isolation of three high molecular weight polysaccharide preparations with potent immunostimulatory activity from Spirulina platensis, aphanizomenon flos-aquae and Chlorella pyrenoidosa, Planta Med., 67, 737, 2001.

48. Hernandez-Corona, A. et al., Antiviral activity of Spirulina maxima against herpes simplex virus type 2, Antiviral Res., 56, 279, 2002.

49. Mao, T.K., Van de Water, J., and Gershwin, M.E., Effects of a Spirulina-based dietary supplement on cytokine production from allergic rhinitis patients, J. Med. Food, 8, 27, 2005.

50. Balachandran, P. et al., Toll-like receptor 2-dependent activation of monocytes by Spirulina polysaccharide and its immune enhancing action in mice, Int. Immuno-pharmacol., 6, 1808, 2006.

51. Grzanna, R. et al., Immolina, a high-molecular-weight polysaccharide fraction of Spirulina, enhances chemokine expression in human monocytic THP-1 cells, J. Altern. Complement. Med., 12, 429, 2006.

52. Jensen, G.S. et al., Consumption of Aphanizomenon flos-aquae has rapid effects on the circulation and function of immune cells in humans, JANA, 2, 50, 2002.

53. Qureshi, M. and Ali, R., Spirulina platensis exposure enhances macrophage phagocytic function in cats, Immunopharmacol. Immunotoxicol., 18, 457, 1996.

54. Qureshi, M.A., Garlich, J.D., and Kidd, M.T., Dietary Spirulina platensis enhances humoral and cell-mediated immune function in chickens, Immunopharmacol. Immunotoxicol., 18, 465, 1996.

55. Hayashi, O., Katoh, T., and Okuwaki, Y., Enhancement of antibody production in mice by dietary Spirulina platensis, J. Nutr. Sci. Vitaminol., 40, 431, 1994.

56. Al-Batshan, H.A. etal., Enhancement of chicken macrophage phagocytic function and nitrite production by dietary Spirulina platensis, Immunopharmacol. Immunotoxicol., 23, 281, 2001.

Hirahashi, T. et al., Activation of the human innate immune system by Spirulina: augmentation of interferon production and NK cytotoxicity by oral administration of hot water extract of Spirulina platensis, Int. Immunopharmacol., 2, 423, 2002. Kim, H.M. et al., Inhibitory effect of mast cell-mediated immediate-type allergic reactions in rats by Spirulina. Biochem. Pharmacol, 55, 1071, 1998. Ayehunie, S. et al., Inhibition of HIV-1 replication by an aqueous extract of Spirulina platensis (Arthrospira platensis), J. Acquir. Immune. Defic. Syndr. Hum. Retrovirol.,

Hayashi, T. et al., Calcium spirulan, an inhibitor of enveloped virus replication, from a blue-green alga Spirulina platensis, J. Nat. Prod., 59, 83, 1996. Witvrouw, M. and De Clercq, E., Sulfated polysaccharides extracted from sea algae as potential antiviral drugs, Gen. Pharmacol, 29, 497, 1997.

Hayashi, K., Hayashi, T., and Kojima, I., A natural sulfated polysaccharide, calcium spirulan, isolated from Spirulina platensis: in vitro and ex vivo evaluation of antiherpes simplex virus and anti-human immunodeficiency virus activities, AIDS Res. Hum. Retroviruses, 12, 1463, 1996.

Hayashi, K. et al., An extract from Spirulina platensis is a selective inhibitor of Herpes simplex virus type 1 penetration into HeLa cells, Phytother. Res., 7, 76, 1993. Peto, R. et al., Can dietary beta-carotene materially reduce human cancer rates? Nature, 290, 201, 1981.

Mishima, T. et al., Inhibition of tumor invasion and metastasis by calcium spirulan (Ca-SP), a novel sulfated polysaccharide derived from a blue-green alga, Spirulina platensis, Clin. Exp. Metastasis, 16, 541, 1998.

Schwartz, J. and Shklar, G., Regression of experimental hamster cancer by beta carotene and algae extracts, J. Oral. Maxillofac. Surg., 45, 510, 1987. Subhashini, J. et al., Molecular mechanisms in C-phycocyanin induced apoptosis in human chronic myeloid leukemia cell line-K562, Biochem. Pharmaco., 68, 453, 2004.

Zhang, H.Q. et al., Chemo- and radio-protective effects of polysaccharide of Spirulina platensis on hemopoietic system of mice and dogs, Acta. Pharmacol. Sin., 22, 1121, 2001.

Kurose, I. et al., Oxidative stress-mediated apoptosis of hepatocytes exposed to acute ethanol intoxication, Hepatology, 25, 368, 1997.

Lieber, C., Cytochrome P450 2E1: its physiological and pathophysiological role, Physiol. Rev., 77, 517, 1997.

Kobayashi, H. et al., Quality control of reactive oxygen species measurement by alcohol-dependent chemiluminescence assay, J. Androl., 22, 568, 2001. Huang, D., Ou, F., and Prior, R.L., The chemistry behind antioxidant capacity assays, J. Agric. Food Chem., 53, 1841, 2005.

Stocker, R. and Ames, B., Potential role of conjugated bilirubin and copper in the metabolism of lipid peroxides in bile, Proc. Natl. Acad. Sci. USA, 84, 8130, 1987. Trull, F.R., Ibars, O., and Lightner, D.A., Conformation inversion of bilirubin formed by reduction of the biliverdin-human serum albumin complex: evidence from circular dichroism, Biochem. Biophys, 298, 710, 1992.

Saxena, P.S. and Kumar, M., Modulatory potential of Spirulinafusiformis on testicular phosphatases in Swiss albino mice against mercury intoxication, Indian J. Exp. Biol., 42, 998, 2004.

Sharma, M.K., Kumar, M., and Kumar, A., Modulatory influence of Ocimum sanctum and Spirulinafusiformis against mercury induced toxicity in liver, Bull. Environ. Sci.,

77. Costa, A.C.A.d. and Franca, F.P.d., Cadmium uptake by Spirulina maxima: toxicity and mechanism, J. Microbiol. Biotech., 14, 579, 1998.

78. Shastri, D., Kumar, M., and Kumar, D.A., Modulation of lead toxicity by Spirulina fusuformis, Phytother. Res., 13, 258, 1999.

79. Kumar, M., Kumar, M., and Kumar, A., Spirulina fusiformis: a food supplement against mercury induced hepatic toxicity, J. Health Sci., 51, 424-430, 2005.

80. Rana, S.V.S., Singh, R., and Verma, S., Protective effects of few antioxidants on liver function in rats treated with cadmium and mercury, Indian J. Exp. Biol., 34, 177, 1996.

81. Pang, Q.S., Guo, B.J., and Ruan, J.H., Enhancement of endonuclease activity and repair DNA synthesis by polysaccharide of Spirulina platensis, Acta. Genet. Sinica (Chinese Journal ofGenetics), 15, 374, 1988.

82. (accessed December, 2006)

83. Yu, A.S. and Keeffe, E.B., Nonalcoholic fatty liver disease, Rev. Gastroenterol. Disord., 2, 11, 2002.

84. Altlparmak, E. et al., Viral and host causes of fatty liver in chronic hepatitis B. World J. Gastroenterol, 11, 3056, 2005.

85. Guha Mazumder, D.N., Arsenic and liver disease, J. Indian Med. Assoc, 99, 311, 2001.

86. Riely, C.A. et al., Acute fatty liver of pregnancy, Semin. Liver Dis., 7, 47, 1987.

87. Adams, L.A. and Talwalkar, J.A., Diagnostic evaluation of nonalcoholic fatty liver disease, J. Clin. Gastroenterol, 40, S34, 2006.

88. Doherty, J.F., Golden, M.H., and Brooks, S.E., Peroxisomes and the fatty liver of malnutrition: an hypothesis, Am. J. Clin. Nutr, 54, 674, 1991.

89. Uchida, T. et al., Alcoholic foamy degeneration—a pattern of acute alcoholic injury of the liver, Gastroenterology, 84, 683, 1983.

90. Davea, R.A. et al., Severe combined hyperlipidemia and retinal lipid infiltration in a patient with Type 2 diabetes mellitus, Lipids Health Dis, 5, 29, 2006.

91. Fan, J.G. et al., Experiment study of steatohepatitis with obesity and hyperlipidemia, Chinese Science, 6, 515, 2000.

92. Mehta, K. et al., Nonalcoholic fatty liver disease: pathogenesis and the role of antioxidants, Nutr. Rev., 60, 289, 2002.

93. Matloff, D.S., Selinger, M.J., and Kaplan, M.M., Hepatic transaminase activity in alcoholic liver disease, Gastroenterology, 78, 1389, 1980.

94. Fan, J.G. et al., Influence of ursodeoxycholic acid on the therapeutic effects of low-calorie diet in obesity and hyperlipidemia rats with steatohepatitis, Zhonghua. Gan. Zang. Bing. Za. Zhi., 10, 43, 2002.

95. Lin, H.Z. et al., Metformin reverses fatty liver disease in obese, leptin-deficient mice, Nat. Med., 6, 998, 2000.

96. Turmellel, Y.P. et al., Rosiglitazone inhibits mouse liver regeneration, FASEB J., 20, 2609, 2006.

97. Cheng, R.Y. et al., Study on preventive effect of betaine on experimental hyperlipidemia and fatty liver in mice, China Pharmacist., 7, 411, 2004.

98. Ersoz, G. et al., Management of fatty liver disease with vitamin E and C compared to ursodeoxycholic acid treatment, Turk. J. Gastroenterol., 16, 124, 2005.

99. Devi, M.A. and Venkataraman, L.V., Hypocholesterolemic effect of blue-green algae spirulina platensis in albino rats, Nutr. Rep. Int., 28, 519, 1983.

100. Kato, T. and Takemoto, K., Effects of Spirulina on hypercholesterolemia and fatty liver in rats. Saitama Med. College, Japan. Japan Nutr. Foods Assoc. Jour., 37, 321, 1984.

González de Rivera, C. et al., Preventive effect of Spirulina maxima on the fatty liver induced by a fructose-rich diet in the rat, a preliminary report, Life Sci., 53, 57, 1993.

Torres-Durán, R.V. et al., Spirulina maxima prevents induction of fatty liver by carbon tetrachloride in the rat, Biochem. Mol. Biol. Int., 44, 787, 1998. Torres-Durán, R.V. et al., Spirulina maxima prevents induction of fatty liver by carbon tetrachloride in the rat, Biochem. Mol. Biol. Int., 44, 787, 1998. Iwasa, M. et al., Spirulina-associated hepatotoxicity, Am. J. Gastroenterol., 97, 3212, 2002.

Rodríguez-Hernández, A. et al., Spirulina maxima prevents fatty liver formation in CD-1 male and female mice with experimental diabetes, Life Sci., 69, 1029, 2001. Nayaka, et al., Cholesterol lowering effect of Spirulina, Nutr. Rep. Int., 37, 1329, 1988.

Becker, E.W. et al., Clinical and biochemical evaluations of Spirulina with regard to its application in the treatment of obesity, Inst. Chem. Pfanz. Nutrition Reports Intl., 33, 565, 1986.

Parikh, P., Mani, U.V., Iyer, U.M., Role of Spirulina in the control of glycemia and lipidemia in type 2 diabetes mellitus, J. Med. Food, 2001, 4(4), 193-199.

Samuels, R. et al., Hypocholesterolemic effect of Spirulina in patients with hyperlipidemic nephritic syndrome, J. Med. Food, 5, 91, 2002.

Pereira, J.N. and Jangaard, N.O., Different rates of glucose and fructose metabolism in rat liver tissue in vitro, Metabolism, 20, 392, 1971.

Cryer, A. et al., Effects of fructose, sucrose and glucose feeding on plasma insulin concentrations and on adipose-tissue clearing-factor lipase activity in the rat, Biochem. J., 140,561, 1974.

Michaelis, O.E.I.V., Nace, C.S., and Szepesi, B., Determination of a specific metabolic effect of dietary disaccharides in the rat, J. Nutr., 105, 1186, 1975. Waterman, R.A. et al., Effects of dietary carbohydrate source on growth, plasma metabolites and lipogenesis in rats, pigs and chicks, Proc. Soc. Exp. Biol. Med., 150, 220, 1975.

Volpe, J.J. and Vagelos, P.R., Regulation of mammalian fatty-acid synthetase. The roles of carbohydrate and insulin, Proc. Natl. Acad. Sci. USA, 71, 889, 1974. Iwata, K., Inayama, T., and Kato, T., Effects of Spirulinaplatensis on fructose-induced hyperlipidemia in rats, J. Japan Soc. Nutr. Food Sci, 40, 463, 1987. Iwata, K., Inayama, T., Kato, T., Effects of Spirulina on plasma lipoprotein lipase activity in rats, J. Nutr. Sci. Vitaminol., 36, 165, 1990.

Maling, H.M., Frank, A., and Horning, M.G., Effect of carbon tetrachloride on hepatic synthesis and release of triglycerides, Biochim. Biophys. Acta., 64, 540, 1962. Pencil, S.D. et al., Carbon tetrachloride-dependent inhibition of lipid secretion by isolated hepatocytes. Characterization and requirement for bioactivation, Biochem. Pharmacol., 33, 2419, 1984.

Glende, E.A. Jr., and Recknagel, R.O., An indirect method demonstrating that CCl4-dependent hepatocyte injury is linked to a rise in intracellular calcium ion concentration, Res. Comm. Chem. Pathol. Pharmacol., 73, 41, 1991. Blé-Castillo, J.L. et al., Arthrospira maxima prevents the acute fatty liver induced by the administration of simvastatin, ethanol and a hypercholesterolemic diet to mice, Life Sci., 70, 2665, 2002.

Takai, Y., Hosoyamada, Y., and Kato, T., Effect of water soluble and water insoluble fractions of Spirulina over serum lipids and glucose resistance of rats, J. Japan Soc. Nutr. Food Sci., 44, 273, 1991.

122. Mitchell, G.V., Jenkins, M.Y., and Grundel, E., Tissue alpha-tocopherol, thiobarbituric acid-reactive substances (TBARS), and glutathione levels in rats fed algal proteins, Ann. N.Y. Acad. Sci., 570, 478, 1988.

123. Kay, R.A., Microalgae as food and supplement, Crit. Rev. Food Sci. Nutr., 30, 555, 1991.

124. Godsland, I.F., The influence of female sex steroids on glucose metabolism and insulin action, J. Intern. Med., 240(Suppl 738), 1, 1996.

125. Nayaka, N., Homma, Y., and Goto, Y., Cholesterol lowering effect of Spirulina. Nutrition Reports Intl., 37, 1329, 1988.

126. Mani, U.V., Desai, S., and Iyer, U., Studies on the long-term effect of spirulina supplementation on serum lipid profile and glycated proteins in NIDDM patients, J. Nutraceut., 2, 25, 2000.

127. Cunnane, S.C., Hepatic triacylglycerol accumulation induced by ethanol and carbon tetrachloride: interactions with essential fatty acids and prostaglandins, Alcohol Clin. Exp. Res., 11, 25, 1987.

128. Murai, A., Furuse, M., and Okumura, J., Involvement of (n-6) essential fatty acids and prostaglandins in liver lipid accumulation in Japanese quail, Am. J. Vet. Res., 57, 342, 1996.

129. Lukivskaya, O.Y., Maskevich, A.A., and Buko, V.U., Effect of ursodeoxycholic acid on prostaglandin metabolism and microsomal membranes in alcoholic fatty liver, Alcohol, 25,99, 2001.

130. Nakanishi, T. et al., y-Linolenic acid prevents conjugated linoleic acid-induced fatty liver in mice, Nutrition, 20, 390, 2004.

131. Chao, Y.C. et al., Alcoholism and alcoholic organ damage and genetic polymorphisms of alcohol metabolizing enzymes in Chinese patients, Hepatology, 25, 112, 1997.

132. Tanaka, F. et al., High incidence of ADH2*1/ALDH2*1 gene among Japanese alcohol dependents and patients with alcoholic liver disease, Hepatology, 23 , 234, 1996.

133. Kato, T., Saiki, I., and Nishino, H., Cancer prevention and inhibition of tumor metastasis by Spirulina components, Dic. Tech Rev., 1, 57, 1995.

134. Poli, G., Pathogenesis of liver fibrosis: role of oxidative stress, Mol. Aspect Med, 21, 49, 2000.

135. Ijzer, J. et al., Morphological characterization of portal myofibroblasts and hepatic stellate cells in the normal dog liver, Comp. Hepatol., 5, 7, 2006.

136. Border, W.A. and Noble, N.A., Transforming growth factor-^ in tissue fibrosis, New Engl. J. Med., 331, 1286, 1994.

137. Bedossa, P. and Paradis, V., Transforming growth factor-^ (TGF-^): a key role in liver fibrogenesis, J. Hepatol., 22(Suppl. 2), 37, 1995.

138. Poli, G. and Parola, M., Oxidative damage and fibrogenesis, Free Radic. Biol. Med., 22, 287, 1997.

139. Crawford, J.M., Liver cirrhosis, in Pathology of the Liver, MacSween, R.N.M. et al., Eds., Churchill Livingstone, Edinburg, 2002, 575.

140. Friedman, S.L., Molecular regulation of hepatic fibrosis, an integrated cellular response to tissue injury, J. Biol. Chem., 275, 2247, 2000.

141. Gressner, A.M., Liver fibrosis: perspectives in pathobiochemical research and clinical outlook, Eur. J. Clin. Chem. Clin. Biochem., 32, 225, 1991.

142. Gressner, A.M., Cytokines and cellular crosstalk involved in the activation of fat-storing cells, J. Hepatol., 22(Suppl. 2), 28, 1995.

143. Suematsu, M. et al., Intravital and electronomicroscopic observation of Ito cells in rat hepatic microcirculation, Microvascular Res., 46, 28, 1993.

Friedman, S.L., Hepatic stellate cells, Prog. Liver Dis., 14, 101, 1996.

Burt, A.D., Review pathobiology of hepatic stellate cells, J. Gastroenterol., 34, 299,

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