Currently, S. platensis is gaining a tremendous attention not only for its nutritional values but also for its potential antioxidant properties. Experimental and epidemiolo-gical evidences suggest that oxidative stress characterized by excessive generation of ROS is a critical player in many pathological states including the inflammatory diseases, neurodegenerative diseases, atherosclerosis, cardiovascular diseases, diabetes mellitus, cancer, and reperfusion injury.108-112 Therefore, the therapeutic use of natural antioxidants appears to be promising in either prevention or protection or both from those diseases among humans. Many algal products appear to improve thenutritional quality of foods because of their ability to combat oxidative damage to cells.113 Spirulina and C-phycocyanin have been shown to protect against the oxidative stress-mediated pathological conditions.104'106'114'115 Studies have shown that Spirulina has potent antioxidant activity 105,106 and scavenges hydroxyl and peroxyl radicals both in vitro and in vivo through its C-phycocyanin constituent.116 C-phycocyanin has been reported not only to scavenge the hydroxyl, peroxyl,114 and superoxide radicals,87 and peroxynitrite117 but also to act as a potent antioxidant by inhibiting the membrane lipid peroxidation.102,118-120 Hence, C-phycocyanin, one of the major biliproteins of Spirulina, is regarded as an effective antioxidant and a free radical scavenger.116
Protection of Drug-Induced Nephrotoxicity by Spirulina
Studies have revealed that Spirulina offers protection against the drug- and chemical-induced toxicity.87,106,121,122 Earlier, we have demonstrated the nephroprotective effects of Spirulina in a rat model of cisplatin-induced nephrotoxicity.40 In our study, Spirulina pretreatment in rats significantly attenuated the cisplatin-induced elevation of the levels of plasma urea, creatinine, and urinary j-NAG (a marker of renal tubular damage) (Figure 7.1). The cisplatin-impaired renal function also
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All you need is a proper diet of fresh fruits and vegetables and get plenty of exercise and you'll be fine. Ever heard those words from your doctor? If that's all heshe recommends then you're missing out an important ingredient for health that he's not telling you. Fact is that you can adhere to the strictest diet, watch everything you eat and get the exercise of amarathon runner and still come down with diabetic complications. Diet, exercise and standard drug treatments simply aren't enough to help keep your diabetes under control.