Percentage of Peritoneal Phagocytic Cells Ingesting Latex Particles From Mice Fed Spirulina
Splenic PFC Phagocytic cell
Means ± SD of 10 mice *p < .05, **p < .01 compared to Control. Source: Hayashi, O., J. Nutr. Sci. Vitaminol., 40, 435, 1994. With permission.
At the beginning of the study we used in-vivo and in-vitro systems to investigate whether S. platensis and its extracts enhance the immune response through primary response and macrophage function in mice. BALB/cAnNCrj mice used in the study were fed laboratory chow containing 10 or 20% (w/w) dried Spirulina. The mice gained body weight normally and consumed an equivalent amount of food and water compared to control mice during the experiment period of 7 weeks. The mice fed on Spirulina diet showed increased numbers of splenic antibody-producing cells, that is, plaque-forming cells (PFC) in the primary immune responses to sheep red blood cells (SRBC) (Table 10.1).12 Immunoglobulin G (IgG)-antibody producing cells (IgG-PFC) in the secondary immune response, however, was hardly affected except for hemagglutination (HA) titer without 2-mercaptoethanol (2-ME) treatment, suggesting that Spirulina affects immunoglobulin M (IgM) antibody synthesis in the initial phase of the immune response. Phagocytic activity of peritoneal-exuded macrophages from the mice was significantly enhanced (Table 10.2). Proliferations of spleen cells by T-cell mitogens, concanavalin A (Con A), and phytohemagglutinin (PHA) were
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