Table 410

Clinical Profile of Nephrotic Patients at Baseline and 4 Months of Spirulina Supplementation (Mean ± SD)

Variables

Baseline

4 months n

Boys/girls Height (cm) Weight (kg)

Body mass index (kg/m2)

Waist (cm) Hip (cm) Waist-hip ratio Medication

30 25/5

30 25/5

114.6 ± 21.6 23.3 ± 12.5 16.6 ± 3.2 58.3 ± 10.2 59.9 ± 12.7 0.98 ± 0.07 Steroids

117.0 ± 22.0 23.1 ± 12.5 16.1 ± 3.1 56.8 ± 9.7 59.3 ± 12.5 0.96 ± 0.05

Steroids

Control group

Experimental group

Control group

A:G Ratio

Globulin

Albumin

Total protein

□ Baseline n4-Months

FIGURE 4.1 Protein status of nephrotic patients (g/dL).

A:G Ratio

Globulin

Albumin

Total protein

Experimental group

]4-Months

□ Baseline n4-Months

]4-Months

FIGURE 4.1 Protein status of nephrotic patients (g/dL).

significant improvement in total protein value suggests the presence of high quality proteins in Spirulina. In addition to this raised levels of albumin and A:G ratio was also seen after 4 months of Spirulina supplementation (Figure 4.1).

Thus, these findings suggest the beneficial effect of good quality proteins in improving the protein status in the Spirulina-supplemented group as against the control group. These results are in line with the trial carried out on asthmatics where Spirulina supplementation slowly improved the protein status.62-64

Hyperlipidemia is commonly seen in nephrotic syndrome patients. Characteristically TG and TC levels are elevated, as are VLDL-C and LDL-C and the concentration of HDL-C has been reported to be variable.65-72 The mechanisms underlying these abnormalities are multifactorial, involving both increased rates of lipoproteins synthesis and defective clearance and catabolism of circulating particles.

In the present study, Spirulina was supplemented for a period of 4 months as it has been proved by many clinical studies1,28,73-76 that it effectively reduces the elevated lipid levels. The results of the present study revealed significant reductions in the lipid levels in control and experimental groups (Table 4.11). But higher reduction in the lipid levels was observed in the experimental groups patients as compared to the control group patients (Table 4.11) after 2 and 4 months of supplementation.

This fall in the atherogenic lipid levels may be due to the supplementation of Spirulina. Various other trials1,28,73-75 have proved that Spirulina effectively reduces the elevated cholesterol levels and similar results have been observed in the current study. The cholesterol reducing property of Spirulina may be due to its high content of GLA,77 which has been discussed earlier in the chapter. The reduction observed in the TG and VLDL-C levels in nephrotic patients after Spirulina supplementation could be attributed to decreased VLDL triglyceride production and increased VLDL-C clearance in the periphery that might have been brought about by the high protein and fiber content of Spirulina. This in turn could have resulted in lowering LDL-C levels in these patients, due to the fact that most of the LDL-C is formed form VLDL-C. As

Was this article helpful?

0 0
Supplements For Diabetics

Supplements For Diabetics

All you need is a proper diet of fresh fruits and vegetables and get plenty of exercise and you'll be fine. Ever heard those words from your doctor? If that's all heshe recommends then you're missing out an important ingredient for health that he's not telling you. Fact is that you can adhere to the strictest diet, watch everything you eat and get the exercise of amarathon runner and still come down with diabetic complications. Diet, exercise and standard drug treatments simply aren't enough to help keep your diabetes under control.

Get My Free Ebook


Post a comment