The Hepatoprotective Effects of Spirulina on Fatty Liver in Laboratory Animals
Wistar rats (male)
1% cholesterol diet
High-fructose diet (68%)
Wistar rats 60% of fructose
CD-1 mice (female, male)
Carbon tetrachloride (i.p. 1 mL/kg, single dose) Carbon tetrachloride (i.p. 1 mL/kg)
Alloxan induced diabetes
Hypercholesterol diet, ethanol and simvastatin
Hypocholesterolemic, hypoglycemic effects; reduced arterioscelerosis and fatty liver Hypolipidemic effect; increased lipoprotein lipase activity Hypocholesterolemic effect; reduced liver triacylglycerol
Reduced liver total lipids, triacylglycerol, cholesterol; increased HDL; restored VLDL, LDL, and TBARS Hypoglycemic, hypotriacylglycerolemic, hypolipidemic effects; restored VLDL + LDL; improved HDL, TBARS Reduced liver cholesterol and triacylglycerol; hypotriacylglycerolemic effect; increased HDL
Kato and Takemoto, 1984
Iwata et al., 1990
Gonzalez de Rivera et al., 1993 Torres-Duran et al., 1998
Torres-Duran et al., 1999
Rodriguez-Hernandez et al., 2001
Spirulina also attenuates alcohol-induced fatty liver through ALDH activity, which is inactive in subjects intoxicated by alcohol, especially in Asian populations.131,132 In an experimental model, the Km value of ALDH decreased from 0.91 to 0.70 mM after treating with Spirulina. However, the activity of alcohol dehydrogenase (ADH) did not change.133 Apparently, Spirulina facilitates alcohol metabolism through enhanced clearance of accumulated aldehyde, which may increase susceptibility to alcoholic liver disease (ALD), such as fatty liver and fibrosis. Summary of numerous reports, which studied the effect of Spirulina on fatty liver, is listed in Tables 6.1 and 6.2.
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All you need is a proper diet of fresh fruits and vegetables and get plenty of exercise and you'll be fine. Ever heard those words from your doctor? If that's all heshe recommends then you're missing out an important ingredient for health that he's not telling you. Fact is that you can adhere to the strictest diet, watch everything you eat and get the exercise of amarathon runner and still come down with diabetic complications. Diet, exercise and standard drug treatments simply aren't enough to help keep your diabetes under control.