Studies on the Anti-Inflammatory Effects of Orally Administered Spirulina and Phycocyanin


Mouse ear inflammation induced by arachidonic acid Mouse ear inflammation induced by TPAa Carrageenan-induced rat paw edema Cotton pellet granuloma




Phycocyanin Phycocyanin

Dosing schedule

1 h before topical application of arachidonic acid

1 h before topical application of TPA

1 h before carrageenan injection Once daily for 7 days after implantation of cotton pellets

Results of Spirulina- or phycocyanin-treated Animals group compared to controls

OF1 mice Dose-dependent inhibition of ear edema (maximum inhibition ~70%); inhibition of prostaglandin E2 levels in the inflamed ear; inhibition of leukotriene B4 levels in the inflamed ear

OF1 mice Dose-dependent inhibition (maximum 46%) of ear edema; dose-dependent reduction (maximum 47%) of myeloperoxidase activity as a marker of neutrophil infiltration Sprague No inhibition of edema (increase in paw thickness)

Dawley at 50 mg/kg, but significant inhibition with 100 and rats 200 mg/kg (maximum 44% )

Sprague No inhibition at 50 mg/kg, but 30% and 36%

Dawley inhibition (reduction of granuloma weight) with rats 100 and 200 mg/kg, respectively


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