Therapeutic Interventions For Inflammation And Oxidative Stress In Aging

The incidence of neurodegenerative diseases increases with age and may be a result of changes in the aged microenvironment that make the brain more susceptible to insults and genetic predispositions of these disease processes. Taking into consideration the above descriptions of oxidative stress and inflammation that occur with age, it becomes evident that bolstering the immune system or finding therapeutic interventions that would shift the balance away from the chronic inflammatory state and towards the alternative inflammatory response maybe a useful strategy. Dietary supplements, as well as, pharmaceuticals have been extensively investigated for their potential as anti-inflammatories and anti-oxidants. With respect to pharmaceuticals, researchers have investigated the potential of NSAIDs in aging. While promising results were initially found with Alzheimers disease,71-73 they were overshadowed by the implications of long-term NSAID usage on the digestive and cardiac system.74 A possible result of this finding was a shift away from manufactured pharmaceuticals and a shift towards a natural occurring source of supplementation. Supplementation of diets with antioxidants can be viewed as a way to support the internal antioxidant system in order to help deter an exacerbation of proinflammatory cytokines. A great natural source of antioxidants are fruits and vegetables. Researchers have used an in vitro assay of oxygen radical absorbance capacity (ORAC) to determine which fruits and vegetables contain the highest oxidative fighting capacity.75 Experiments using dietary interventions with fruit and vegetable supplements (blueberry, strawberry, spinach, and vitamin E) high in ORAC activity have resulted in successful amelioration of such age-related declines as muscarinic receptor sensitivity, noradrenergic modulation of cerebel-lar Purkinje neurons, calcium regulation, and Morris water maze performance, among others.66,76,77

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Supplements For Diabetics

Supplements For Diabetics

All you need is a proper diet of fresh fruits and vegetables and get plenty of exercise and you'll be fine. Ever heard those words from your doctor? If that's all heshe recommends then you're missing out an important ingredient for health that he's not telling you. Fact is that you can adhere to the strictest diet, watch everything you eat and get the exercise of amarathon runner and still come down with diabetic complications. Diet, exercise and standard drug treatments simply aren't enough to help keep your diabetes under control.

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