Hypoxic Liver Cell Necrosis

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Ischemic necrosis of the liver may follow episodes of congestive heart failure, hypovolemic shock, hepatic artery thrombosis, myocardial infarction and cardiac tamponade.119 The underlying mechanism involves a reduction of hepatic blood flow which results in centrilobular hepatic necrosis. In many cases the reduction in blood flow is transient, resulting in minimal liver injury. However, massive necrosis will result in FHF associated with marked serum transaminase level elevation.120 Many of these patients are not suitable candidates for liver transplantation due to severe cardiovascular disease.

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