With initiation of inflammation there is increased leucocyte production and rapid recruitment to the inflamed site. There is also activation of mediator cascades including the production of cytokines, chemokines, acute phase proteins, free radicals, complement, coagulation pathway components, and focal upregulation of adhesion molecule expression. The "antiinflammatory" response includes the glucocorticoids, cytokines (interleukin (IL)-4, IL-10 and IL-1 receptor antagonist (IL-1ra)) and other mechanisms such as shedding of adhesion molecules.39-41

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