Effect of Rate of Tissue Metabolism and Tissue Blood Flow on Interstitial PCO2. Tissue capillary blood flow and tissue metabolism affect the Pco2 in ways exactly opposite to their effect on tissue Po2. Figure 40-7 shows these effects, as follows:
1. A decrease in blood flow from normal (point A) to one quarter normal (point B) increases peripheral tissue Pco2 from the normal value of 45 mm Hg to an elevated level of 60 mm Hg. Conversely, increasing the blood flow to six times normal (point C) decreases the interstitial
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