Figure 656

Functional organization of the villus. A, Longitudinal section. B, Cross section showing a basement membrane beneath the epithelial cells and a brush border at the other ends of these cells.

valvulae conniventes (or folds of Kerckring), which increase the surface area of the absorptive mucosa about threefold. These folds extend circularly most of the way around the intestine and are especially well developed in the duodenum and jejunum, where they often protrude as much as 8 millimeters into the lumen.

Also located on the epithelial surface of the small intestine all the way down to the ileocecal valve are literally millions of small villi. These project about 1 millimeter from the surface of the mucosa, as shown on the surfaces of the valvulae conniventes in Figure 65-5 and in individual detail in Figure 65-6. The villi lie so close to one another in the upper small intestine that they touch in most areas, but their distribution is less profuse in the distal small intestine. The presence of villi on the mucosal surface enhances the total absorptive area another 10-fold.

Finally, each intestinal epithelial cell on each villus is characterized by a brush border, consisting of as many as 1000 microvilli 1 micrometer in length and 0.1 micrometer in diameter protruding into the intestinal chyme; these microvilli are shown in the electron micrograph in Figure 65-7. This increases the surface area exposed to the intestinal materials at least another 20-fold.

Thus, the combination of the folds of Kerckring, the villi, and the microvilli increases the total absorptive area of the mucosa perhaps 1000-fold, making a tremendous total area of 250 or more square meters for the entire small intestine—about the surface area of a tennis court.

Figure 65-6A shows in longitudinal section the general organization of the villus, emphasizing (1) the advantageous arrangement of the vascular system for absorption of fluid and dissolved material into the portal blood and (2) the arrangement of the "central lacteal" lymph vessel for absorption into the lymph.

Figure 65-6B shows a cross section of the villus, and Figure 65-7 shows many small pinocytic vesicles, which are pinched-off portions of infolded enterocyte membrane forming vesicles of absorbed fluids that have been entrapped. Small amounts of substances are absorbed by this physical process of pinocytosis.

Extending from the epithelial cell body into each microvillus of the brush border are multiple actin filaments that contract rhythmically to cause continual movement of the microvilli, keeping them constantly exposed to new quantities of intestinal fluid.

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Essentials of Human Physiology

Essentials of Human Physiology

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