Absorption of sodium through the intestinal epithelium. Note also osmotic absorption of water—that is, water "follows" sodium through the epithelial membrane.
passively "dragged" by the positive electrical charges of the sodium ions.
Active transport of sodium through the basolateral membranes of the cell reduces the sodium concentration inside the cell to a low value (about 50 mEq/L), as also shown in Figure 65-8. Because the sodium concentration in the chyme is normally about 142 mEq/L (that is, about equal to that in plasma), sodium moves down this steep electrochemical gradient from the chyme through the brush border of the epithelial cell into the epithelial cell cytoplasm. This provides still more sodium ions to be transported by the epithelial cells into the paracellular spaces.
Osmosis of the Water. The next step in the transport process is osmosis of water into the paracellular spaces. This occurs because a large osmotic gradient has been created by the elevated concentration of ions in the paracellular space. Much of this osmosis occurs through the tight junctions between the apical borders of the epithelial cells, but much also occurs through the cells themselves. And osmotic movement of water creates flow of fluid into and through the paracellular spaces and, finally, into the circulating blood of the villus.
Aldosterone Greatly Enhances Sodium Absorption. When a person becomes dehydrated, large amounts of aldos-terone almost always are secreted by the cortices of the adrenal glands. Within 1 to 3 hours this aldosterone causes increased activation of the enzyme and transport mechanisms for all aspects of sodium absorption by the intestinal epithelium. And the increased sodium absorption in turn causes secondary increases in absorption of chloride ions, water, and some other substances.
This effect of aldosterone is especially important in the colon because it allows virtually no loss of sodium chloride in the feces and also little water loss. Thus, the
function of aldosterone in the intestinal tract is the same as that achieved by aldosterone in the renal tubules, which also serves to conserve sodium chloride and water in the body when a person becomes dehydrated.
Was this article helpful?
This ebook provides an introductory explanation of the workings of the human body, with an effort to draw connections between the body systems and explain their interdependencies. A framework for the book is homeostasis and how the body maintains balance within each system. This is intended as a first introduction to physiology for a college-level course.