Figure 744

Beta Switch Program

Beta Switch Program by Sue Heintze

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Mechanism of activation of a G protein-coupled receptor. When the hormone activates the receptor, the inactive a, b, and g G protein complex associates with the receptor and is activated, with an exchange of guanosine triphosphate (GTP) for guanosine diphosphate (GDP). This causes the a subunit (to which the GTP is bound) to dissociate from the b and g subunits of the G protein and to interact with membrane-bound target proteins (enzymes) that initiate intracellular signals.

Leptin

Leptin receptor

Leptin receptor

Jak2 P

Activation of enzymes

Physiological effects

Jak2 P

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Essentials of Human Physiology

Essentials of Human Physiology

This ebook provides an introductory explanation of the workings of the human body, with an effort to draw connections between the body systems and explain their interdependencies. A framework for the book is homeostasis and how the body maintains balance within each system. This is intended as a first introduction to physiology for a college-level course.

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