Figure 746

Mechanisms of interaction of lipophilic hormones, such as steroids, with intracellular receptors in target cells. After the hormone binds to the receptor in the cytoplasm or in the nucleus, the hormone-receptor complex binds to the hormone response element (promoter) on the DNA. This either activates or inhibits gene transcription, formation of messenger RNA (mRNA), and protein synthesis.

▼ Lipophilic hormone Diffusion f

Cytoplasmic receptor

Extracellular fluid

Target cell

Ribosome

Target cell

Cytoplasmic receptor

Ribosome mRNA

Nuclear envelope

Nuclear pore mRNA

Nuclear envelope

Nuclear pore

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Essentials of Human Physiology

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