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Shift to right:

(1) Increased hydrogen ions

(2) Increased CO2

(3) Increased temperature

(4) Increased BPG

"I—I—I—I—I—I—I—I—I—I—I—I—I—I

0 1 0 2 0 30 40 50 6 0 7 0 80 90100110120130140 Pressure of oxygen in blood (Po2) (mm Hg)

Shift to right:

(1) Increased hydrogen ions

(2) Increased CO2

(3) Increased temperature

(4) Increased BPG

"I—I—I—I—I—I—I—I—I—I—I—I—I—I

0 1 0 2 0 30 40 50 6 0 7 0 80 90100110120130140 Pressure of oxygen in blood (Po2) (mm Hg)

oxygen-hemoglobin dissociation curve to the left and upward. Therefore, the quantity of oxygen that binds with the hemoglobin at any given alveolar Po2 becomes considerably increased, thus allowing greater oxygen transport to the tissues.

Effect of BPG to Shift the Oxygen-Hemoglobin Dissociation Curve. The normal BPG in the blood keeps the oxygen-hemoglobin dissociation curve shifted slightly to the right all the time. In hypoxic conditions that last longer than a few hours, the quantity of BPG in the blood increases considerably, thus shifting the oxygen-hemoglobin dissociation curve even farther to the right. This causes oxygen to be released to the tissues at as much as 10 mm Hg higher tissue oxygen pressure than would be the case without this increased BPG. Therefore, under some conditions, the BPG mechanism can be important for adaptation to hypoxia, especially to hypoxia caused by poor tissue blood flow.

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Essentials of Human Physiology

Essentials of Human Physiology

This ebook provides an introductory explanation of the workings of the human body, with an effort to draw connections between the body systems and explain their interdependencies. A framework for the book is homeostasis and how the body maintains balance within each system. This is intended as a first introduction to physiology for a college-level course.

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