Portions of the carbon dioxide dissociation curve when the Po2 is 100mmHg or 40mmHg. The arrow represents the Haldane effect on the transport of carbon dioxide, as discussed in the text.
promoting carbon dioxide transport than is the Bohr effect in promoting oxygen transport.
The Haldane effect results from the simple fact that the combination of oxygen with hemoglobin in the lungs causes the hemoglobin to become a stronger acid. This displaces carbon dioxide from the blood and into the alveoli in two ways: (1) The more highly acidic hemoglobin has less tendency to combine with carbon dioxide to form carbaminohemoglobin, thus displacing much of the carbon dioxide that is present in the car-bamino form from the blood. (2) The increased acidity of the hemoglobin also causes it to release an excess of hydrogen ions, and these bind with bicarbonate ions to form carbonic acid; this then dissociates into water and carbon dioxide, and the carbon dioxide is released from the blood into the alveoli and, finally, into the air.
Figure 40-15 demonstrates quantitatively the significance of the Haldane effect on the transport of carbon dioxide from the tissues to the lungs. This figure shows small portions of two carbon dioxide dissociation curves: (1) when the Po2 is 100 mm Hg, which is the case in the blood capillaries of the lungs, and (2) when the Po2 is 40 mm Hg, which is the case in the tissue capillaries. Point A shows that the normal Pco2 of 45 mm Hg in the tissues causes 52 volumes per cent of carbon dioxide to combine with the blood. On entering the lungs, the Pco2 falls to 40 mm Hg and the Po2 rises to 100 mm Hg. If the carbon dioxide dissociation curve did not shift because of the Haldane effect, the carbon dioxide content of the blood would fall only to 50 volumes per cent, which would be a loss of only 2 volumes per cent of carbon dioxide. However, the increase in Po2 in the lungs lowers the carbon dioxide dissociation curve from the top curve to the lower curve of the figure, so that the carbon dioxide content falls to 48 volumes per cent (point B). This represents an additional 2 volumes per cent loss of carbon dioxide. Thus, the Haldane effect approximately doubles the amount of carbon dioxide released from the blood in the lungs and approximately doubles the pickup of carbon dioxide in the tissues.
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