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Figure 27-19

Approximate relationship between glomerular filtration rate (GFR) and plasma creatinine concentration under steady-state conditions. Decreasing GFR by 50 per cent will increase plasma creatinine to twice normal if creatinine production by the body remains constant.

Renal plasma flow

5.S5 mg/ml

Figure 27-20

Measurement of renal plasma flow from the renal clearance of para-aminohippuric acid (PAH). PAH is freely filtered by the glomerular capillaries and is also secreted from the peritubular capillary blood into the tubular lumen. The amount of PAH in the plasma of the renal artery is about equal to the amount of PAH excreted in the urine. Therefore, the renal plasma flow can be calculated from the clearance of PAH (CPAH). To be more accurate, one can correct for the percentage of PAH that is still in the blood when it leaves the kidneys. PPAH, arterial plasma PAH concentration; upah, urine PAH concentration; V, urine flow rate.

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Essentials of Human Physiology

Essentials of Human Physiology

This ebook provides an introductory explanation of the workings of the human body, with an effort to draw connections between the body systems and explain their interdependencies. A framework for the book is homeostasis and how the body maintains balance within each system. This is intended as a first introduction to physiology for a college-level course.

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