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Publishing Director: Linda Belfus Acquisitions Editor: William Schmitt Managing Editor: Rebecca Gruliow Publishing Services Manager: Tina Rebane Project Manager: Mary Anne Folcher Design Manager: Steven Stave Marketing Manager: John Gore

Cover illustration is a detail from Opus 1972 by Virgil Cantini, Ph.D., with permission of the artist and Mansfield State College, Mansfield, Pennsylvania.

Chapter opener credits: Chapter 43, modified from © Getty Images 21000058038;Chapter 44, modified from © Getty Images 21000044598;Chapter 84, modified from © Corbis.

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Last digit is the print number: 987654321

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ELSEVIER Sabre Foundation

My Family

For their abundant support, for their patience and understanding, and for their love

Arthur C. Guyton For his imaginative and innovative research For his dedication to education For showing us the excitement and joy of physiology And for serving as an inspirational role model

Arthur C. Guyton, M.D. 1919-2003

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Brain Blaster

Brain Blaster

Have you ever been envious of people who seem to have no end of clever ideas, who are able to think quickly in any situation, or who seem to have flawless memories? Could it be that they're just born smarter or quicker than the rest of us? Or are there some secrets that they might know that we don't?

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