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Clotting process in a traumatized blood vessel. (Modified from Seegers WH: Hemostatic Agents, 1948. Courtesy of Charles C Thomas, Publisher, Ltd., Springfield, IL.)

Clotting process in a traumatized blood vessel. (Modified from Seegers WH: Hemostatic Agents, 1948. Courtesy of Charles C Thomas, Publisher, Ltd., Springfield, IL.)

Table 36-1

Clotting Factors in Blood and Their Synonyms

Clotting Factor

Fibrinogen Prothrombin Tissue factor Calcium Factor V

Factor VII

Factor VIII

Factor IX

Factor X Factor XI

Factor XII Factor XIII Prekallikrein High-molecular-weight kininogen Platelets

Synonyms

Factor I Factor II

Factor III;tissue thromboplastin Factor IV

Proaccelerin;labile factor; Ac-globulin (Ac-G)

Serum prothrombin conversion accelerator (SPCA);proconvertin; stable factor Antihemophilic factor (AHF); antihemophilic globulin (AHG); antihemophilic factor A Plasma thromboplastin component (PTC);Christmas factor; antihemophilic factor B Stuart factor;Stuart-Prower factor Plasma thromboplastin antecedent (PTA);antihemophilic factor C Hageman factor Fibrin-stabilizing factor Fletcher factor Fitzgerald factor;HMWK

(high-molecular-weight) kininogen which subsequently form connective tissue all through the clot, or (2) it can dissolve. The usual course for a clot that forms in a small hole of a vessel wall is invasion by fibroblasts, beginning within a few hours after the clot is formed (which is promoted at least partially by growth factor secreted by platelets). This continues to complete organization of the clot into fibrous tissue within about 1 to 2 weeks.

Conversely, when excess blood has leaked into the tissues and tissue clots have occurred where they are not needed, special substances within the clot itself usually become activated. These function as enzymes to dissolve the clot, as discussed later in the chapter.

Prothrombin activator

Prothrombin

Thrombin

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