Pain Receptors and Their Stimulation

Pain Receptors Are Free Nerve Endings. The pain receptors in the skin and other tissues are all free nerve endings. They are widespread in the superficial layers of the skin as well as in certain internal tissues, such as the periosteum, the arterial walls, the joint surfaces, and the falx and tentorium in the cranial vault. Most other deep tissues are only sparsely supplied with pain endings; nevertheless, any widespread tissue damage can summate to cause the slow-chronic-aching type of pain in most of these areas.

Three Types of Stimuli Excite Pain Receptors—Mechanical, Thermal, and Chemical. Pain can be elicited by multiple types of stimuli. They are classified as mechanical, thermal, and chemical pain stimuli. In general, fast pain is elicited by the mechanical and thermal types of stimuli, whereas slow pain can be elicited by all three types.

Some of the chemicals that excite the chemical type of pain are bradykinin, serotonin, histamine, potassium ions, acids, acetylcholine, and proteolytic enzymes. In addition, prostaglandins and substance P enhance the sensitivity of pain endings but do not directly excite them. The chemical substances are especially important in stimulating the slow, suffering type of pain that occurs after tissue injury.

Nonadapting Nature of Pain Receptors. In contrast to most other sensory receptors of the body, pain receptors adapt very little and sometimes not at all. In fact, under some conditions, excitation of pain fibers becomes progressively greater, especially so for slow-aching-nauseous pain, as the pain stimulus continues. This increase in sensitivity of the pain receptors is called hyperalgesia. One can readily understand the importance of this failure of pain receptors to adapt, because it allows the pain to keep the person apprised of a tissue-damaging stimulus as long as it persists.

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Essentials of Human Physiology

Essentials of Human Physiology

This ebook provides an introductory explanation of the workings of the human body, with an effort to draw connections between the body systems and explain their interdependencies. A framework for the book is homeostasis and how the body maintains balance within each system. This is intended as a first introduction to physiology for a college-level course.

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  • Noah
    What types of stimuli excite pain receptors?
    4 years ago
  • isengrim
    What chemical stimuli at tissue level excite pain receptors?
    3 years ago
  • AUNE
    What chemical stimumili at tissue level excite pain receptors?
    3 years ago
  • lee wilkerson
    What stimulates pain receptors?
    2 years ago
  • columbus
    What stimulates pain receptors in arteries?
    2 years ago
  • diamante romani
    What kind of stimulation affect pain receptors?
    1 year ago
  • Andrea
    How can race affect pain receptors?
    9 months ago
  • Fredegar Sackville
    What stimulates pain receptors in autonomically innervated tissues?
    6 months ago
  • Veli
    What would stimulate pain receptors in autonomically innervated tissues?
    6 months ago
  • steven
    What would stimulate pain receptors in automicallly innervated tissues?
    6 months ago
  • Romilda
    Can prostaglandins excite pain receptors directly?
    27 days ago

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