{D-Xylulose-5-phosphate "Ï

D-Ribose-5-phosphate J


D-Glyceraldehyde-3-phosphate J

{Fructose-6-phosphate "Ï

Erythrose-4-phosphate J

Net reaction:

Glucose + 12NADP+ + 6H2O 6CO2+12H + 12NADPH

Figure 67-8

Pentose phosphate pathway for glucose metabolism.

When the glycolytic pathway for using glucose becomes slowed because of cellular inactivity, the pentose phosphate pathway remains operative (mainly in the liver) to break down any excess glucose that continues to be transported into the cells, and NADPH becomes abundant to help convert acetyl-CoA, also derived from glucose, into long fatty acid chains.This is another way in which energy in the glucose molecule is used other than for the formation of ATP—in this instance, for the formation and storage of fat in the body.

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Essentials of Human Physiology

Essentials of Human Physiology

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