Posttranslational Protein Modifications

AMPA ion channels undergo phosphorylation, which may affect synaptic plasticity and is tightly regulated by phos-phokinases such as PKA, PKC, CaMKII, and others. Phosphorylation generally potentiates AMPA receptor activation, with evidence that it occurs by keeping the channel open longer or more often. AMPA receptors also contain 4 to 6 N-glycosylation sites that influence binding of ligands to the receptor pocket, with effects that depend on the type of ligand and the subunit's flip/flop specification.

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Free Yourself from Panic Attacks

Free Yourself from Panic Attacks

With all the stresses and strains of modern living, panic attacks are become a common problem for many people. Panic attacks occur when the pressure we are living under starts to creep up and overwhelm us. Often it's a result of running on the treadmill of life and forgetting to watch the signs and symptoms of the effects of excessive stress on our bodies. Thankfully panic attacks are very treatable. Often it is just a matter of learning to recognize the symptoms and learn simple but effective techniques that help you release yourself from the crippling effects a panic attack can bring.

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