Summary

Because glucocorticoids target almost all organ systems to regulate a myriad of functional responses, alterations in their level and/or activity can lead to diverse functional consequences.

REFERENCES

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McEwen, B. S. (1994). Corticosteroids and hippocampal plasticity. Annals of the New York Academy of Sciences, 746, 134-142.

Munck, A., Guyre, P. M., & Holbrook N. J. (1984). Physiological functions of glucocorticoids in stress and their relation to pharmacological actions. Endocrine Reviews, 5, 25-44.

Reul, J. M. H. M., & De Kloet, E. R. (1985). Two receptor systems for corticosterone in the rat brain: Microdistribution and differential occupation. Endocrinology, 117, 2505-2512.

Tsigos, C., & Chrousos, G. P. (1994). Physiology of the hypothalamic-pituitary-adrenal axis in health and dysregulation in psychiatric and autoimmune disorders. Endocrinology and Metabolism Clinics of North America, 23, 451-466.

Van Cauter, E., & Turek, F. W. (1995). Endocrine and other biological rhythms. In L. J. DeGroot (Ed.), Endocrinology: Vol. 3 (pp. 2487-2548). Philadelphia: W. B. Saunders.

Uma Rao

Russell E. Poland

UCLANeuropsychiatric Institute

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