Numerous treatments have been applied to CFS patients, with various results. Those with the best experimental data to support efficacy include graded exercise training and cognitive-behavioral therapy. Low-dose corticosteroids have been reported to improve symptoms in two studies. Trials of antidepressants have yielded a confusing welter of positive and negative results, but in general these agents appear to be significantly less effective for CFS than for mood or anxiety disorders. Other CFS treatments with at least one positive study to their credit include growth hormone, selegiline, immunoglobulin, ampligen, nicotinamide adenine dinucleotide (NADH), and omega-3 fatty acids. Although treatments may ameliorate symptoms, to date, none will resolve the disorder.

Charles L. Raison

Andrew H. Miller

Dimitris Papanicolaou

Emory University School of Medicine

William C. Reeves

Centers for Disease Control and Prevention

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