Foods to avoid if you have Psoriasis
Psoriasis of the border of the scalp. Psoriasis in this location is often difficult to distinguish from seborrheic dermatitis. ( Smith Kline & French Laboratories) Figure 14-2. Psoriasis on elbows of a 17-year-old girl. Moderately extensive psoriasis in classic distribution on back and knees. ( K.U.M.C. Roche Laboratories) Figure 14-3. Psoriasis. Figure 14-3. Psoriasis. Figure 14-4. Psoriasis. Figure 14-4. Psoriasis. Psoriasis is a common, chronically recurring, papulosquamous disease, characterized by various sized silvery-white, scaly patches seen most commonly on the elbows, the knees, and the scalp. Generalized pustular psoriasis (pustular psoriasis of von Zambusch) and generalized erythrodermic psoriasis can be life-threatening, usually related to overwhelming sepsis and rarely seen in association with adult respiratory distress syndrome. A form of pustular psoriasis localized to the palms and soles (pustular psoriasis of Barber, acropustulosis) can be a difficult...
Psoriasis of fingernails Pitting, red areas occur under nail with resulting detachment psoriasis is elsewhere, usually no fungi are found (see Chap 14). Psoriasis of toenails This may be impossible to differentiate from tinea, because many psoriatic nails have some secondary fungal invasion.
Acitretin (Soriatane), another synthetic derivative of vitamin A, is useful for pustular and exfoliative psoriasis. Both Accutane and Soriatane have severe side effects, including fetal abnormalities. They should never be prescribed unless the physician and patient thoroughly understand the potential dangers of these vitamin A derivatives. Vitamin D. No skin lesions have been attributed to lack of this vitamin. Vitamin D and vitamin D2 (calciferol) have been used orally in the treatment of lupus vulgaris. Vitamin D3 (Dovonex ointment) is used topically for psoriasis.
Human skin is a highly efficient, self-repairing barrier which permits terrestrial life by regulating heat and water loss from the body while preventing the ingress of noxious chemicals or micro-organisms. It is the largest organ of the human body providing around 10 of the body mass of an average person and an area of approximately 1.8 m2. The tissue can be examined at various levels of complexity. Simplistically, skin can be regarded merely as a physical barrier with more sophistication introduced by considering the various skin layers, providing barriers in parallel. We can introduce barriers in series by considering drug transport through pores in the tissue. Degrees of complexity also exist when examining basic structures and functions of the membrane. In some extreme cases it may be that topical drug delivery is limited by metabolic activity within the membrane. Alternatively, immunological responses may prevent the clinical use of a formulation that has proven to be optimal...
The type of skin lesion, more than the cause, influences the kind of local medication used. The old adage, If it's wet, use a wet dressing, and if it's dry, use an ointment, is true in most cases. For example, to treat a patient with an acute oozing, crusting dermatitis of the dorsum of the hand, whether due to poison ivy or soap, the physician should prescribe wet soaks. For a chronic-looking, dry, scaly patch of psoriasis on the elbow, an ointment is indicated because an aqueous lotion or a wet dressing would only be more drying. Bear in mind, however, that the type of skin lesion can change rapidly under treatment. The patient must be followed closely after beginning therapy. An acute oozing dermatitis treated with soaks can change, in 2 or 3 days, to a dry, scaly lesion that requires a cream or an ointment. Conversely, a chronic dry patch may become irritated with too strong therapy and begin to ooze. Actions Antiinflammatory, antipruritic, and cleansing Indications Dandruff,...
Psoriasis The papulosquamous dermatoses include several specific entities that predominantly affect the chest and the back with clinically similar macular, papular, and scaly lesions. The most common diseases in the group are psoriasis, pityriasis rosea, tinea versicolor, lichen planus, seborrheic dermatitis, secondary syphilis, and drug eruptions. The last three conditions are considered elsewhere in this book. To be complete with regard to the differential diagnoses of this group, the following rarer diseases can also be included parapsoriasis and its variants, lichen nitidus, and pityriasis rubra pilaris.
A chronic pustular dermatitis of hands and feet identical with or related to pustular psoriasis, pustular bacterid, and dermatitis repens. Anhidrosis. 8. The partial or complete absence of sweating, seen in ichthyosis, extensive psoriasis, scleroderma, prickly heat, vitamin A deficiency, one form of ectodermal dysplasia and other diseases. Partial anhidrosis is produced by many antiperspirants. Anthralin. 37, 133. A proprietary name for dihydroxyanthranol, which is a strong reducing agent useful in the treatment of chronic cases of psoriasis. Its action is similar to that of chrysarobin. Arsenic. 85. Inorganic arsenic preparation include Fowler's solution and Asiatic pills and were used in the treatment of resistant cases of psoriasis. Can cause arsenical pigmentation, actinic keratoses, Bowen's disease, squamous cell carcinoma, and underlying malignancies (especially lung and bladder). Other sources are well water and industrial sources such as pesticides, sheep dips,...
A flu-like illness may occur at the time of acute seroconversion. An evanescent morbilliform rash has been associated with this syndrome. Seborrheic dermatitis is seen in up to 50 of patients with HIV infection. Clinically, seborrheic dermatitis in these patients tends to be more florid and less responsive to therapy than in the nonimmunocompromised host. Psoriasis and Reiter's disease have been reported in 1 to 5 of patients infected with HIV. Psoriasis may flare in those with previously
The initial cause (a bite, stasis dermatitis, contact dermatitis, seborrheic dermatitis, tinea cruris, psoriasis) may be very evanescent, but it is generally agreed that the chronicity of the lesion is due to the nervous habit of scratching. It is a rare patient who will not volunteer the information or admit, if questioned, that the itching is worse when he or she is upset, nervous, or tired. Why some people with a minor skin injury respond with the development of a lichenified patch of skin and others do not is possibly due to the personality of the patient. Psoriasis Several patches on the body in classic areas of distribution family history of disease classic silvery whitish scales sharply circumscribed patch (see Chap. 1.4). External otitis is a descriptive term for a common and persistent dermatitis of the ears due to several causes. The agent most frequently blamed for this condition is fungus, but pathogenic fungi are rarely found in the external ear. The true causes...
Koilonychia may be seen as part of many other skin diseases such as lichen planus or psoriasis. There is an autosomal dominant variety that has no associated internal disease but may be associated with total leukonychia. It may be seen in normal children within the first year or two of life. Injury to the nail may cause the koilonychia seen in the toenails of those who pull rickshas and fingernails of mechanics.
Certain physiologic skin changes occur. Perspiration is increased. Hyper-pigmentation of the abdominal midline, nipples, vulva, and face (chloasma) is seen, and, in some brunettes, nevi and freckles also become more prominent and more pigmented. Malignant melanoma is not more common in pregnancy. Hypertrichosis of the scalp may be unnoticed until the excess hair begins to be shed after delivery. Striae of breasts, abdomen, and thighs appear. The skin diseases of pregnancy are herpes gestationis (see Fiig.M 26-11D-E), impetigo herpetiformis, vulvar pruritus (often due to candidal infection), palmar erythema, spider hemangiomas, pyogenic granulomas, rarely erythema multiforme, and pedunculated fibromas. The following dermatoses are usually better, or disappear, during pregnancy psoriasis, acne (can be worse), alopecia areata, and, possibly, systemic scleroderma. MENOPAUSE. Common physiologic changes in the skin of women during menopause include hot flashes, increased...
Erupted skin surface will allow increased water loss from the body. Psoriasis is a chronic recurring non-infectious scaling skin condition characterised by erythe-matous plaques covered with silvery scales. For topical therapy the loss of skin barrier integrity has been shown to be valuable for targeting drugs to the required site of action while minimising side effects (Anigbogu et al., 1996). Lichenoid eruptions are characterised by intensely itchy flat-topped papules while eczema is a further non-infectious eruptive condition, in which blistering occurs. Contact dermatitis can result from a direct irritant action of a substance on the skin (irritant contact dermatitis) or further exposure, following previous sensitisa-tion of the skin, from a contact allergen (allergic contact dermatitis). Irritant dermatitis is the more common of the two manifestations, and can be caused by many chemicals, solvents and detergents sodium lauryl sulphate was used to induce irritant dermatitis before...
In contrast with these MDC subsets, pDCs are not resident cells of normal skin and mucosa (Gilliet et al., 2004 Wollenberg et al., 2002) but are present in HPV-related cervical cancer (Bontkes et al., 2005), skin melanoma lesions (Salio et al., 2003), lupus erythematosus (Farkas et al., 2001), psoriasis (Nestle et al., 2005), allergic contact dermatitis (Bangert et al., 2003) and in the nasal mucosa as early as 6 h after allergen challenge (Jahnsen et al., 2000), suggesting an active recruitment of blood pDCs to the site of peripheral inflammation. Furthermore, pDC recruitment to the skin has been observed in a therapeutic setting in which skin tumors were treated topically with TLR7 agonist imiquimod (Urosevic et al., 2005). As will be discussed further, pDC trafficking has many similarities with T cells, both being attracted to the site of inflammation by chemokines (SDF-1 CXCR3-ligands).
Among the proteins that have been reported as targets of biomedical interest for development of aptamers as therapeutics, particularly relevant is Tenascin-C (TN-C). It is a large, extracellular matrix glycoprotein that is overexpressed during tissue remodeling such as wound healing, atherosclerosis, psoriasis, and tumor growth (21). To isolate oligonucleotide that can target anticancer drug delivery, selection yielded an aptamer that bound to TN-C with a Kd of 5 nM (22). The TN-C aptamer is currently being developed for tumor-imaging applications (23).
With the progression of our knowledge on DC biology, it appears that DCs are central to the immune system. They are among the first cells to encounter a pathogen, together with epithelial cells, and their intrinsic properties as well as mode of activation have a great impact on the subsequent adaptive immune response. This central role is illustrated by the increasing number of disease situations where MDC function was found to be abnormally increased, such as allergy (Holt and Stumbles, 2000 Lambrecht et al., 2001 Soumelis and Liu, 2004) and autoimmunity (Pulendran et al., 2001c), or decreased, such as neoplasia (Banchereau and Palucka, 2005) or various immune deficiencies, including, but not restricted to, HIV. Although more recently described, pDCs have also been implicated in various pathologic conditions. pDC activation to produce type I IFNs could be a major factor in the pathophysiology of autoimmune diseases such as lupus erythematosus (Blanco et al., 2001 Lovgren et al., 2004...
A reducing agent that hastens keratinization when it is applied to the skin. It can be incorporated into petrolatum or chloroform but must be used with great caution and in mild strength such as 0.25 to 3 . Mainly used in treatment of resistant cases of psoriasis and tinea cruris.
This condition is marked by increased proliferation of epidermal keratinocytes, associated with an infiltrate of neutrophils and lymphocytes. T-lymphocyte functions are necessary to induce and maintain psoriasis lesions. Psoriasis responds to a variety of immunosuppressive treatments, including fusion toxins that specifically target only T cells. It is also possible to induce psoriasis in human skin grafted onto immunodeficient mice by transferring T cells. Bacterial superantigens, which activate T cells, may have a role in flaring psoriasis. Most inflammatory skin disease responds to topical or systemic corticosteroids. However, long-term use of corticosteroids has significant toxicity and there are multiple nonsteroidal immunosuppressive agents used in dermatology. Steroid sparing agents used in the treatment of autoimmune bullous diseases include azathioprine, cyclophosphamide, dapsone, gold, and methotrexate. Immunosuppressive agents useful for psoriasis include...
(effect sizes of approximately 0.5 p 0.0001). Beneficial effects of this program were also found at three-year follow-up (Miller et al., 1995). According to a recent review of literature (Kabat-Zinn, 2003), the effectiveness of MBSR was demonstrated in psoriasis, immune function disorders, chronic pain, anxiety disorders, and prostate cancer.
Twenty-nail dystrophy is characterized by lackluster appearance with longitudinal striations, roughness, and some pitting, which may be seen in all 20 nails, usually in children. This may improve spontaneously over some years. Although this problem was described as a primary nail disease, many authors believe these are the nail changes of psoriasis, lichen planus, or alopecia areata that are seen without other manifestations of the disorder. Less commonly, IgA deficiency and autoimmune hematologic abnormalities are associated. It may represent a subgroup of endogenous eczema with a predilection for the nail matrix or an autoimmune response in the nail matrix.
A primary fungal infection of the hand or hands is quite rare. In spite of this fact, the diagnosis of fungal infection of the hand is commonly applied to cases that in reality are contact dermatitis, atopic eczema, pustular bacterid, or psoriasis. The best differential point is that tinea of the hand usually is seen only on one hand, not bilaterally.
Most teenagers have a mild form of acne this can become serious and may also occur in the adult years. Rosacea somewhat resembles acne but is not related to it. Usually found in middle-aged adults, rosacea causes flushing, acnelike bumps on the skin and discomfort. Bacterial infections can cause boils or other symptoms. Dermatitis, or skin irritation, can result from exposure to certain chemical compounds or even from psychological stress. Lice, mites, and other parasites may find homes on the skin. Red patches on the skin, covered with silvery gray scaly areas, are symptoms of psoriasis.
Sun-reactive skin typing of white-skinned persons became necessary when psoralens and ultraviolet light therapy were developed for the treatment of psoriasis. Type I persons always burn, never tan type II persons usually burn and tan with difficulty type III persons sometimes have a mild sunburn and tan about average and type IV persons rarely burn and tan with ease. The typing has been further expanded to type V for brown-skinned persons and type VI for black-skinned persons, both of whom never sunburn and do tan.
Correct diagnosis of a fungal infection is necessary. An oral antifungal drug should not be prescribed for a patient if the diagnosis has not been confirmed. Systemic antifungal agents are of no value in treating atopic eczema, contact dermatitis, psoriasis, pityriasis rosea, and so on.
In Finland PICD was noted in 139 of 4,320 cases of occupational skin disease during a 7-year observation period 4 . However, the actual number is probably higher, because mechanical forces are accepted as natural occurrences by most employees and are not reported. Thirty-two percent of individuals presenting with PICD are atopic and 6 suffer from psoriasis 5 . PICD is aggravated occupationally in 84 of cases, in 6 related to hobbies and in 6 due to medical devices. Body sites most likely affected are the hands (35 ), face (26 ), limbs (15 ) and fingers (7 ) 6 . Of 29,000 patients, an incidence of 1.4 of PICD was noted 1 . The mean age of the patients in the physical irritant study group was 39 years, with a greater proportion of males (ratio M F 1.3 1.0).
Onycholysis is the distal or lateral separation of the nail plate from the nail bed. Probably psoriasis, fungal infection, and trauma (physical and chemical) from overly vigorous manicuring are among the more common causes. An allergic or irritant reaction to nail cosmetics may also be a culprit (see Fig.28-3A.).
|Psoriasis No More||psoriasisnomore.net|
Natural Treatments For Psoriasis
Do You Suffer From the Itching and Scaling of Psoriasis? Or the Chronic Agony of Psoriatic Arthritis? If so you are not ALONE! A whopping three percent of the world’s populations suffer from either condition! An incredible 56 million working hours are lost every year by psoriasis sufferers according to the National Psoriasis Foundation.