The discovery in the 1950s that imipramine and iproniazid had antidepressant properties was soon followed by the recognition that they acted on monoamine systems. This laid the foundation for two interrelated but logically distinct theories which have dominated biological research into depression and its treatment ever since:
1. the hypothesis that monoamine function is abnormal in depression and
2. the hypothesis that altering monoamine function can treat the depressed state. The second hypothesis suggests that changes in monoamine function are sufficient, or possibly even necessary, to alleviate depression and, by extension, implies that a common mechanism could underlie the action of all antidepressant drugs in spite of differences in their acute pharmacology. In this chapter we will explore an aspect of the second hypothesis by reviewing human data investigating the effect of antidepressants on serotonin (5-hydroxytryptamine, 5-HT) function using neuroendocrine challenge tests.
Was this article helpful?
Learning About How To Defeat Depression Can Have Amazing Benefits For Your Life And Success! Discover ways to cope with depression and melancholic tendencies! Depression and anxiety particularly have become so prevalent that it’s exceedingly common for individuals to be taking medication for one or even both of these mood disorders.